In this article we present the solution to the problem related to Application load error Q:0000065450 in Fallout 4. Moreover, we have two special methods that can be used for fixing the issue on your choice.
Method 1: Right click on Fallout 4 in steam library, go to its properties, open game data tab and run cache integrity check hoping everything will be great.
Method 2: Shutdown off your antivirus for launching game normally.
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